Ortho Molecular Products
Ortho Molecular Products® Natural D-Hist®
The Natural D-Hist® formula includes optimal support for nasal and sinus passageways for individuals who anticipate seasonal changes. Supports Immune Balance in Hypersensitive Individuals Supports Sinus and Respiratory Health Promotes Normal Viscosity of Mucus Supports Healthy Nasal Passages Natural D-Hist® is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. The formula includes quercetin, bromelain, stinging nettles leaf and N-acetyl cysteine. The powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. Suggested Use: Loading Dose: 2 capsules three times per day for 7-10 days or as recommended by your health care professional. Maintenance: 2 or more capsules per day or as recommended by your health care professional. Quercetin Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging Nettles Leaf Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response. Bromelain Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort. N-Acetyl Cysteine N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health. Vitamin C Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$25.67 - $49.21
Ortho Molecular Products® CitraNOX®
Highlights Multidimensional Support for Optimal Blood Pressure Helps Maintain Endothelial Cell Elasticity Helps Preserve Coronary Arteries Enhances Circulating Nitric Oxide Levels Stress placed on coronary arteries as a result of normal cardiac function is an expected part of the aging process. This stress can lead to disruptions in arterial function, proliferation of vascular smooth muscle, decreases in circulating nitric oxide (NO) levels, and eventually vasocontraction of key coronary arteries. CitraNOX® provides a blend of targeted nutrients designed to help dampen this stress by maintaining normal inflammatory balance, balancing NO levels, maintaining smooth muscle integrity, and optimizing vasodilation of key coronary arteries. Suggested Use: 4 capsules per day or as recommended by your health care professional. L-Citrulline L-citrulline is one of three dietary amino acids in the urea cycle responsible for converting ammonia into urea as well as for the production of NO, an important cellular signaling molecule. In this process, L-citrulline is the natural precursor of L-arginine, the substrate used by endothelial nitric oxide synthase to produce NO. Quercetin Dihydrate A flavonoid found in a variety of botanicals, vegetables and fruits, quercetin is a potent antioxidant that inhibits inducible ICAM-1 expression, an important pathway for maintaining normal inflammatory balance. Quercetin has been shown to support normal inflammatory balance by directly inhibiting the activity of NFkB, similar to turmeric. Quercetin is also known for its ability to improve endothelial cell dysfunction by maintaining normal inflammatory balance in specific pathways. MegaNatural® BP Grape Seed Extract MegaNatural® BP is a premium grape seed extract made in California from a special seed blend extracted with water from a variety of white wine grape seeds. Grapes and grape products contain phenolic compounds found to have health-promoting properties, particularly in cardiovascular wellness. Grape seed extract has a high concentration of phenolic compounds, which have been found to support healthy arterial dilation and blood flow.
$55.00
Ortho Molecular Products® Digestzyme-V
Highlights Supports Healthy Digestion and Maximizes Nutrient Absorption Targeted Enzyme Support for Food Sensitivities Designed to Enhance the Benefits of a Plant-Rich Diet Stimulates the Release and Production of Natural DigestiveEnzymes in the Pancreas Supports Gastric Acid Balance and Digestive Function Because of our hectic lifestyle, and the way we often consume food that is frequently overcooked, digestion can often be less than optimal. Poor digestion can produce bloating and occasional gas, cramping, diarrhea or constipation, and even lead to incomplete digestion of food proteins that have been linked to food sensitivities. Conversely, more thorough digestion of foodstuffs with enzymes prevents foods from being fermented in the gut and the proliferation of "bad" bacteria and yeast at the expense of "good" intestinal bacteria. More complete digestion of carbohydrates removes the food source for these bad organisms. Another benefit of enzymes is that more nutrition can be derived from food. In addition, regular bowel movements result from this better digestion. Digestzyme-V is specifically designed to support digestion and help unlock more nutrition from food. Digestzyme-V is a comprehensive blend of acid-resistant, plant-based enzymes designed to help maximize the digestion and absorption of nutrients from food. Each capsule includes lipase, amylase, lactase, CereCalase® and protease to aid in the digestion of protein, fat, starches, fiber and other difficult to digest foods known to cause food sensitivities. CereCalase®, a special blend of hemicellulase, beta-glucanase and phytase, is specially formulated to digest the cell walls of plants, providing better nutrition from a plant-based diet. Digestzyme-V also contains Gentian root, a traditional bitter herb as well as artichoke, a natural choleretic, added to stimulate the body’s natural production of enzymes and bile. Suggested Use: 1 capsule 15 minutes before a meal or as recommended by your health care professional. Enzyme Depletion Chronic overuse of certain medications may contribute to side effects stemming from low acid production, including poor mineral absorption and poor absorption of B12. In addition, an estimated 30% of Americans suffer from low levels of acidity. The depletion of stomach acidity due to medications and age are further compounded by the age-related decline of enzyme production which both influence the breakdown of foods into absorbable nutrients. This can lead to suboptimal nutritional status of certain vitamins and minerals and insufficient enzyme activation in the stomach. Enzyme Blend Digestive enzymes have a long history of use for those who need digestive enzyme support. In the past, animal enzymes were preferred to vegetable enzymes for their protein digesting strength though they required a narrower pH window of 6.5-7.5 in order to be activated. Digestzyme-V utilizes new, plant- based enzymes which function within a broader pH range of 2.5-8.5, and still offer the digestive strength of animal-based enzymes. This broad pH window of activity makes it especially helpful for individuals with lower gastric acid levels or inconsistent pH’s. Each enzyme has been tested in pH, temperature, and gastric survivability studies to ensure enzyme activity. In addition, Digestzyme-V also includes DPP4, one of the primary components of peptidase, which has been shown to digest and neutralize gluten. This action may help to support gluten-sensitive individuals who ingest it inadvertently. The blend of proteases in Digestzyme-V is also effective in breaking down proteins from soy, whey, and casein from milk products. Lipases for fat breakdown as well as amylases for carbohydrate breakdown are also included for full- spectrum digestive support. Sustaining a Plant-Rich Diet Digestzyme-V offers additional support for those who have difficulty digesting plant-based foods. Optimal breakdown of plant cell walls is complex and nutrients contained within the cell walls can be difficult to absorb; for this reason, CereCalase®, pectinase, xylanase, cellulose, glucoamylase and alphagalactosidase, plant enzymes not produced in the body, are added to the formula. The addition of CereCalase® assists in the breakdown of plant cell walls and helps to release trapped nutrients from plant materials. Alpha-galactosidase is also included for difficult-to-digest foods such as beans, legumes, and cruciferous vegetables, to help people maintain a plant-rich diet. Both animal and human trials indicate that the supplementation of phytase helps release these nutrients and improve the nutrition of the consumer. Furthermore, a large portion of the fibrous components of botanicals are composed of non-starchy polysaccharides (NSPs), the primary ones being hemicelluloses and beta-glucans. These two compounds can alter the transit times of foods, bind digestive enzymes, and trap essential plant constituents. Enzymes which degrade these components have been shown to improve the digestibility and nutrient profiles of plant foods and products. Gentian and artichoke are also added to help stimulate the body’s own digestive processes to help achieve optimal digestive capacity. Gentian Root and Artichoke Herbalists have used bitters, including gentian, to stimulate natural digestive enzymes in the mouth and stomach for hundreds of years. Studies have shown that artichoke, categorized as a choleretic, stimulates the body’s natural production of bile, which is responsible for emulsifying fats in our diets. Artichoke also increases the surface area of fats, which allows enzymes to more efficiently break them down. Artichoke and gentian root provide an excellent vegetarian alternative to ox bile, which is traditionally used in digestive supplements to support bile production.
$42.69
Ortho Molecular Products® EstroDIM®
Highlights EstroDIM® is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) to support balanced estrogen metabolism. Supports Estrogen Balance Supports Proper Estrogen Metabolism for Women and Men Improves Estrogen Detoxification Pathways Provides Cellular Antioxidant Support for DNA Stability Hormones (especially estrogen) are critically important in human development and tissue repair. However, estrogen’s proliferative effects must be balanced and controlled for optimal health. Therefore, to ensure proper hormonal balance, estrogen synthesis and detoxification should be supported. Estrogen has several downstream metabolites, of which some are beneficial while others possess potentially harmful biological activity. By keeping hormones in balance and ensuring the body can process estrogen properly, cruciferous vegetable metabolites (i.e., I3C and DIM) work together to maintain cellular health. EstroDIM® is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) to support balanced estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance, breast and prostate health. I3C & DIM Indole-3-carbinol (I3C) and diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C and DIM have been shown to induce some phase I and phase II biotransformation genes in preclinical models through pathways such as Nrf2, suggesting I3C and DIM may have a role in detoxification. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, the enzyme that converts androgens to estrogen. Suggested Use: 1 capsule per day or as recommended by your health care professional.
$30.17 - $52.86
Ortho Molecular Products® CM Core®
Highlights CM Core® provides multidimensional support for cardiovascular health by maintaining healthy cholesterol levels and supporting blood sugar balance already within normal levels. Multidimensional Support for Cardiometabolic Health Enhances Cell Signaling for Efficient ATP Production Supports Blood Sugar Balance Already Within Normal Levels Maintains Healthy Cholesterol Levels Already Within the Normal Range Clinical research shows that maintaining optimal cardiovascular health should address multiple metabolic factors. CM Core®, a formula backed by extensive clinical research, is designed to address several factors associated with ideal cardiometabolic health. The powerful combination of berberine and alpha lipoic acid (ALA) helps maintain heart function, metabolism, antioxidant status, and lipid and glucose levels. CM Core® provides a powerful formula for those seeking to optimize the multiple mechanisms of cardiovascular and metabolic health. Suggested Use: 3 capsules per day or as recommended by your health care professional. Berberine Berberine is a plant extract that has been used in Chinese and Ayurvedic medicine for over 2,500 years for its broad range of health-promoting properties. Berberine can be found in the roots and stems of plants such as Hydastatis canadensis (goldenseal), Coptis chinensis (goldenthread), Berberis aquifolium (Oregon grape) and Berberis vulgaris (barberry). Clinical trials have demonstrated that berberine administration supports cardiovascular health in a number of synergistic ways including maintaining blood pressure, supporting healthy heart contraction and rhythm and supporting healthy cholesterol levels. Alpha Lipoic Acid (ALA) Alpha lipoic acid (ALA) is a nutrient required for cellular metabolism, specifically the breakdown of carbohydrates and fatty acids. ALA has been shown to support blood sugar balance already within normal levels by activating AMPK, a major regulator of cellular energy. ALA is also a potent antioxidant. It scavenges free radicals while aiding in the regeneration of the body's antioxidants including vitamin C, vitamin E and glutathione. Through its antioxidant-boosting mechanisms, ALA helps maintain healthy blood vessel and circulatory health.
$54.25
Ortho Molecular Products® DHEA 5mg
Highlights Each tablet provides 5 mg of DHEA derived from the wild yam, allowing for incremental oral supplementation and flexibility with numerous hormone-balancing and stress-fighting protocols. Promotes Healthy Hormonal Balance Supports Mood Regulation Balances the Stress Response System by Improving Cortisol-to-DHEA Ratios Maintains Healthy Aging and Normal Inflammatory Balance Supports Bone Health Dehydroepiandrosterone (DHEA) is a steroid hormone precursor that helps maintain healthy hormone levels and helps support the stress response system. DHEA functions as the counterpart to the stress hormone cortisol. Maintaining healthy DHEA levels is crucial for balancing the catabolic effects of cortisol. DHEA and its sulfate, DHEAs, are the most abundant steroid hormones in the human body and can be found in blood, saliva, urine and cerebrospinal fluid (CSF). DHEA serves as a “buffer” reservoir to be used for the intracellular synthesis of various estrogens and androgens throughout the human body. DHEA production peaks during the second decade of life. Beginning in the early 30s, DHEA levels typically decline by 10% per decade. In addition to the normal decline associated with aging, other possible causes of a decline in DHEA production include inflammation, blood sugar imbalances and long-term stress. Suggested Use: 1 tablet per day or as recommended by your health care professional. Mood Regulation Elevated cortisol levels can play a major role in normal mood regulation. DHEA counterbalances high levels of cortisol and also brightens mental outlook. DHEA can easily cross the blood-brain barrier, which is crucial for supporting brain function. Supplementation with DHEA has been shown to support mood regulation by increasing levels of β-endorphins, quieting glutamate (N-methyl-D-aspartate) receptors and protecting against the effects of glucocorticoids in the brain. Bone Health DHEA has been examined in numerous studies for its role in supporting bone health. Possible theories regarding DHEA's ability to support bone health include DHEA functioning as a precursor for the formation of estradiol and androgens, which promotes healthy bone formation by increasing levels of insulin-like growth factor. Inflammatory Balance DHEA has been shown to maintain normal inflammatory balance by inhibiting the activation of nuclear factor-kβ and the secretion of inflammatory compounds, such as IL-6 and IL-2. Maintaining normal inflammatory balance has been shown to be crucial in patients with gastrointestinal challenges. Aging Research has indicated that DHEA naturally supports healthy aging. Hormonal Balance DHEA is a precursor to estrogen and testosterone. In addition, DHEA may also have physiological actions unrelated to its function as a hormone precursor, as DHEA receptors are also present in human muscle cells. Clinical studies using oral doses of DHEA have demonstrated its ability to maintain hormonal balance.
$16.16
Ortho Molecular Products® Super Aloe 450
Highlights Super Aloe includes ingredients for regularity that work fast, without the artificial additives and associated cramping common in some products. Also available in convenient blister packs. Supports Gastrointestinal Function Supports Bowel Regularity Cape aloe has been used for thousands of years to promote the health of epithelial tissue, including the bowel lining. Cape aloe contains a class of phytonutrient compounds called anthraquinone glycosides. When ingested, these compounds are activated through bacterial metabolism in the gut, promote water retention in the stool, and stimulate peristalsis in the large intestine. By causing active chloride secretion, cape aloe increases the water and electrolyte content in the stool and eases elimination without artificial additives and cramping associated with other therapies. Super Aloe is intended for the relief of occasional constipation. Cape aloe, the solid residue obtained by evaporating liquid aloe ferox, has been shown in the research to affect regularity due to its influence on colon peristalsis, which it triggers to contract, resulting in accelerated intestinal passage. This formulation Super Aloe is available as 250 and 450 mg capsules, two potencies to provide tailored natural support for elimination. Suggested Use: 1 capsule at bedtime (allow 24 hours before redosing) or as recommended by your health care professional. Cape Aloe Despite the lack of published studies, aloe preparations have been in the United States Pharmacopoeia for more than 100 years. Anecdotal evidence suggests cape aloe supports normal inflammatory response in the gastrointestinal tract. Studies demonstrate that cape aloe increases stool bulk and bowel transit time and improves microflora balance. Cape aloe also supports the colon to help maintain a healthy gastrointestinal tract
$26.00
Ortho Molecular Products® Cerenity®
Cerenity® includes advanced neurotransmitter support to fight stress and promote relaxation. Supports a State of Calmness and Relaxation Increases Serotonin and GABA Production in the Brain Addresses Neurotransmitter Signaling Systems Supports Occasional Sleeplessness Neurotransmitters are the chemical messengers that regulate mood, memory, sleep cycle and daily stress. Adequate neurotransmitter production depends on an adequate supply of amino acids, vitamins and minerals in the diet. Cerenity® is a comprehensive formula designed to address daily stress by increasing the production of the calming neurotransmitters serotonin and gamma-amino butyric acid (GABA). Cerenity® also includes key ingredients that quickly increase the production of alpha brain waves resulting in a relaxed and effortless state of alertness. Suggested Use: 3 capsules taken 1-3 times per day or as recommended by your health care professional. L-Theanine L-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. It has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation. PharmaGABATM Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and is a primary component of the body’s stress-fighting mechanisms. Cerenity® includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA™. It is produced naturally by the friendly bacteria, Lactobacillus hilgardii. In contrast to synthetic GABA sources, PharmaGABA™ has been shown in published research studies to promote a state of relaxation. Inositol Inositol is a B vitamin that is an important component of cell membrane signaling. As part of the cellular signaling system of the central nervous system, inositol is crucial for the release of neurotransmitters from within the nerve cells. Taurine Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. 5-HTP 5-hydroxytryptophan (5-HTP) is an amino acid intermediate that is directly converted into the mood-regulating neurotransmitter serotonin. Maintaining a healthy serotonin level is important for regulating appetite and sleep cycle and for supporting a sense of calmness. Micronutrients Cerenity® includes essential nutrients that are required for the synthesis of serotonin and GABA neurotransmitters. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6 (P-5-P), vitamin C, zinc and magnesium. Magnesium is a mineral that calms the nervous system by binding to glutamate receptors, which reduces excitatory neurotransmitter activity. The combination of the minerals zinc and magnesium helps reduce glutamate to non-toxic levels, providing significant neuroprotection. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$57.25
Ortho Molecular Products® Lipitrol OX
Highlights Lipitrol OX contains three powerful antioxidant extracts designed to support the body's ability to maintain healthy levels of oxidized LDL (oxLDL), which research indicates is an important factor in maintaining proper endothelial function and cardiovascular health. Maintains Normal Inflammatory Balance Promotes Healthy Cholesterol Levels Already Within the Normal Range Provides Antioxidant Support for Blood Vessels Supports the Body’s Ability to Maintain Healthy Levels of oxLDL Helps Maintain Optimal Endothelial Health Supports Healthy HDL Function The endothelium is a one cell thick layer which lines our blood vessels that acts as an interface between the blood and the rest of the body. Current research indicates maintaining levels of oxidized low-density lipoproteins (oxLDL) already within the normal range is one of the most important markers for endothelial and cardiometabolic health. Lipitrol OX is designed to support the body’s ability to maintain healthy levels of oxidized LDL, which research indicates is an important factor in maintaining proper endothelial function and cardiovascular health. Containing standardized antioxidant extracts from olive fruit, pomegranate, and French maritime pine bark, Lipitrol OX synergistically maintains normal endothelial function, supports healthy blood pressure levels and a normal inflammatory response. Suggested use: 2 capsules per day or as recommend by your health care professional. Oligopin Maritime Pine French maritime pine bark extract (FMPBE) contains oligomeric procyanidins (OPC), a specific type of flavonoid showing strong antioxidant properties which help support healthy levels of circulating oxLDL. Oligopin is a standardized FMPBE with a unique profile characterized by high concentration of OPC and an absence of tannins, resulting in improved bioavailability. MEDITEANOX™ Olive Fruit Extract Olive oil possess naturally occurring phenolic compounds that have been investigated for their beneficial role in the Mediterranean diet’s ability to maintain arterial and cardiometabolic health. MEDITEANOX™ is an olive fruit extract standardized for hydroxytyrosol (HT), one of the olive’s primary polyphenols with potent antioxidant effects, showing beneficial effects in supporting healthy plasma oxLDL levels and antioxidant capacity, as well as supporting optimal cytokine balance. Pomanox™ Pomegranate Extract Pomegranate fruit has been a symbol of health and longevity used by many cultures throughout history, with research now revealing the fruits health promoting properties are due to a unique class of polyphenols called punicalagins. Pomanox™ uses a propriety extraction method producing a polyphenol spectrum corresponding to whole fresh pomegranates, enabling natural synergy between PC and other pomegranate polyphenols which helps maintain cardiovascular health.
$46.22
Ortho Molecular Products® K-Force
Highlights Vitamins K and D act in synergy in the process of supporting and maintaining bone, cardiovascular and immune health. Ortho Molecular Products is the exclusive provider of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7. Supports Healthy Calcium Balance Promotes Optimal Bone Health Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells that break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Along with vitamin D, another key nutrient required for overall wellness, these two nutrients act in synergy to support and maintain bone and cardiovascular health. Current research has found high concentration supplementation, at 180 mcg/day, results in improved clinical results compared to lower-dose supplementation. K-FORCE provides 180 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, along with 5,000 IU of vitamin D3 for optimal support of bone and cardiovascular health. Suggested Use: 1 capsule per day or as recommended by your health care professional. Vitamin K Depletion Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in two main forms: K1 (phylloquinone), derived from foods such as green leafy vegetables and K2 (menaquinone), which is a group of related compounds differentiated by their side chains. Numerous studies have shown that vitamin K2 as MK-7 is the more bioavailable form of the nutrient 7 and more powerfully influences bone building than K1. Bone Health Supplementation of K2 has repeatedly been shown to help maintain bone density and strength among women. Research conducted on Japanese populations has found superior bone health among women who more frequently consumed MK-7-rich nattō than those who did not. Cardiovascular Health and Blood Sugar Balance Vitamin K also plays a key role in supporting the cardiovascular system and healthy blood sugar balance. In a large population study, those who consumed high amounts of K2 had significantly improved cardiovascular markers compared to those given vitamin K1. Triage Theory The Triage Theory states that in the face of nutrient inadequacies, nature ensures the short-term survival of a cell is protected at the expense of long-term consequences. Vitamin K is an excellent example of this theory. Hypothetically, a short-term deficiency in vitamin K would lead to a reduction in blood clotting. This direct threat to survival does not happen because the body uses its metabolic reserve of vitamin K to ensure immediate needs are met. If prolonged, this dip into nutrient reserves leads to a long-term deficiency in vitamin K. Though not directly threatening immediate survival, long-term deficiencies are linked to bone fragility, arterial calcification and genomic instability.
$48.79
Ortho Molecular Products® K-Force Max
Vitamins K and D act in synergy in the process of supporting and maintaining bone, cardiovascular and immune health. Ortho Molecular Products is the exclusive provider of MenaQ7® Pro, the most widely studied form of vitamin K2 as MK-7. Supports Healthy Calcium Balance Promotes Optimal Bone Health Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells which break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Along with vitamin D, another key nutrient required for overall wellness, these two nutrients act in synergy to support and maintain bone and cardiovascular health. Current research has found high concentration supplementation, at 180 μg/day, results in improved clinical results compared to lower-dose supplementation. K-FORCE MAX provides 180 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, along with 10,000 IU of vitamin D3 for optimal support of bone and cardiovascular health. Directions1 capsule per day or as recommended by your health care professional. Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in two main forms: K1 (phylloquinone), derived from foods such as green leafy vegetables and K2 (menaquinone), which is a group of related compounds differentiated by their side chains. Numerous studies have shown that vitamin K2 as MK-7 is the more bioavailable form of the nutrient 7 and more powerfully influences bone building than K1.
$33.16
Ortho Molecular Products® Collagen Factors
Collagen Factors provides cofactors and precursors that support joints, hair, skin, nails, fascia and other connective tissues. Maintains Healthy Joint Function for Normal Mobility and Lubrication Provides Precursors for Generation of Cartilage, Tendons, Ligaments, Fascia and Skin Promotes a Healthy Joint Environment by Supporting Normal Activity of Cytokines and Catabolic Enzymes Collagen Factors provides targeted precursors and cofactors known to be involved in the biochemical processes that support healthy connective tissue in the skin, tendons, ligaments, cartilage, joints and bone extracellular matrix. This formulation contains patented hyaluronic acid, MSM, free-form amino acids, key minerals and vitamin C.Suggested Use:2 capsules per day or as recommended by your health care professional. Hyaluronic Acid Extract Mobilee® is a patented, high-molecular-weight hyaluronic acid (HA), which enhances the viscoelastic, lubricating properties of synovial fluid. In addition, it contains collagen and other glycosaminoglycans (GAGs) to enhance skin and joint health. Hyaluronic acid also plays a role in the biophysical, biochemical and cell regulation processes in joint synovial tissues. Scientific evidence shows that Mobilee® supports chondrocytes and synovial cells function, and is two to four times more active than fermented sources of HA in nourishing and supporting the health of synovial fluid. The latest clinical research includes HA in proactive and maintenance approaches to joint care that supports normal range-of-motion. Research suggests that Mobilee® supports the quality of synovial fluid by positively influencing synovial HA concentration, and by reducing the expression of degradative factors in synovial fluid.Specific Precursors Collagen is comprised of and formed from the amino acids proline and lysine. Lysine is an essential amino acid the body relies on adequate dietary intake for its involvement in the synthesis of connective tissues. Proline is well-known for its involvement in the triple helix of collagen—it is regularly spaced with glycine in the amino acid sequence of collagen fiber, which together comprise about 50% of total collagen sequencing. Proline contributes to not only collagen formation, but muscle, tendons and skin. Lysine helps support the linking and stabilization of collagen, and contributes to the collagen matrix formation of veins, arteries and capillaries. During procollagen synthesis, both proline and lysine are hydroxylated to hydroxyproline and hydroxylysine, a reaction requiring vitamin C as a cofactor. Inadequate levels of vitamin C can impact this reaction, resulting in incomplete formation of the helical structure, in which leads to a delicate and easily destroyed structure. Vitamin C is combined with two amino acids—lysine and proline—to form procollagen. Procollagen is then used to manufacture one of several types of collagen found in different tissues throughout the body.Targeted Cofactors Zinc is an essential trace mineral that supports DNA synthesis, cell division, cell membrane structure, immune function, and protein synthesis. Requirements are highest when the body’s repair system is most active. MSM is responsible for the flexible disulfide bonds between cells, including those that make up connective tissue and the skin. It blocks undesirable chemical and physical cross-linking of collagen and preserves connective tissue pliancy, which is crucial for supporting healthy collagen. MSM has been shown to significantly increase plasma glutathione levels, an additional benefit in maintaining collagen’s defensive mechanisms against oxidative stress. Multiple clinical studies also show that MSM, in combination with other joint health ingredients, supports tendon and joint health. Manganese assists the growth and development of normal bone and the synthesis of cartilage. Manganese is also a structural component of antioxidant enzymes, and aids in amino acid production. During the tissue synthesis process, which requires an increased production of collagen, manganese is required for the activation of prolidase, an enzyme that functions to provide the amino acid proline, for collagen formation in human skin cells. Nutritional co-factors required for tissue regeneration include zinc, vitamin C and amino acids. Inadequacy of these nutrients impacts endogenous collagen production and connective tissue synthesis. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$32.09
Ortho Molecular Products® Thyrotain
Highlights Helps to Maintain Healthy Thyroid Function Promotes the Synthesis of Thyroid Hormones Helps Support Conversion of T4 to T3 Improves Cellular Sensitivity to Thyroid Hormones Supports a Healthy Inflammatory and Antioxidant Balance Thyrotain is a comprehensive formulation that provides a blend of nutrients and botanicals working in synergy to support thyroid health. Thyrotain includes L-tyrosine and iodine, which make up the backbone of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The addition of zinc, selenium, vitamin A, and the botanical guggulipid activate enzymes that enhance the conversion of T4 into the active thyroid hormone T3. Vitamin A and zinc also help improve cellular sensitivity to thyroid hormones. Turmeric, along with the antioxidants vitamin C and E and N-acetyl cysteine (NAC), provide a powerful combination of antioxidants that boost thyroid health by reducing free radical stress. Suggested Use: 4 capsules per day or as recommended by your health care professional. Vitamins and Minerals Thyroid hormones are made from amino acid L-tyrosine and iodine. Iodine is an essential trace mineral and is necessary for the synthesis of thyroid hormones, as it is one of the most important components of the hormones T4 and T3. The thyroid gland absorbs iodine from the blood and incorporates it into thyroid hormones. In addition to supporting thyroid hormone production, research shows iodine acts as an antioxidant, supporting a healthy thyroid gland and protecting a variety of tissues, including mammary tissue, the eyes and gastrointestinal lining. Normal thyroid status is dependent on adequate levels of many trace minerals for the synthesis and metabolism of thyroid hormones. The minerals zinc and selenium are required cofactors for the enzymes that convert T4 to T3. Selenium deficiency has been shown to contribute to decreased T4 to T3 conversion. Supplementation of selenium can also help decrease thyroperoxidase (TPO) antibodies in thyroid autoimmunity. Supplementation with zinc has been shown to restore T3 levels in patients with normal T4 and low T3, demonstrating its role in the conversion process. Vitamin A and vitamin E are also necessary for normal thyroid hormone manufacturing. Antioxidants (Turmeric, Vitamins C and E, and N-Acetyl Cysteine) Increased free radical activity can compromise healthy T4 to T3 conversion. N-acetyl cysteine (NAC), a precursor to the body’s master antioxidant glutathione, boosts thyroid health by accelerating antioxidant activity in the thyroid gland. The Complete Turmeric Matrix, along with the antioxidants vitamin C and E, has been shown to promote a healthy thyroid gland due to direct antioxidant activity. Ashwagandha Ashwagandha (Withania somnifera) has been used in Aryuvedic and indigenous medical systems for over 3,000 years and has been examined in research studies for its stress-lowering effects. Ashwagandha has been found to exhibit GABA agonist activity, which accounts for its ability to relax the nervous system. Ashwagandha may also stimulate thyroid activity indirectly, via its effects on cellular antioxidant systems, specifically by increasing the antioxidant enzymes superoxide dismutase and catalase and reducing lipid peroxidation. Guggulipid The gum resin of the guggul plant has been used in Ayurvedic medicine in India for nearly 3,000 years. Guggulipid (Commiphora mukul) has been shown to support thyroid function, primarily by decreasing lipid peroxidation in the liver, the principal site of T3 generation. Guggul extract has also been shown to have thyroid-stimulating action by increasing iodine uptake by the thyroid gland and increasing the activities of thyroid peroxidase and protease.
$45.26
Ortho Molecular Products® Cerenity PM
Highlights Formulated Specifically for Patients with Occasional Sleeplessness Promotes Calmness and Relaxation Supports Normal, Uninterrupted Sleep Provides Comprehensive Neurotransmitter Support Sleep is the body’s way of metabolically and psychologically resetting itself. The body’s circadian rhythm is regulated by an internal biological clock with an approximate 24-hour cycle. In order to maintain restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-aminobutyric acid (GABA), the relaxing and sleep-regulating neurotransmitters, as well as the sleep-regulating hormone melatonin. The synergistic ingredients in Cerenity PM, including 5-HTP, PharmaGABA® and taurine, boost levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep. Suggested Use: 4 capsules taken one to two hours before bedtime or as recommended by your health care professional. 5-HTP The sleep-regulating hormone melatonin requires the essential amino acid L-tryptophan for conversion. A deficiency of L-tryptophan in the diet can lead to low serotonin and melatonin levels, which can contribute to sleep challenges. L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion. PharmaGABA® Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in activating the sleep cycle in the evening. Cerenity PM includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA®. In a study utilizing 100 mg of PharmaGABA®, supplemented before bedtime, PharmaGABA® was shown to reduce sleep latency by 20%, while increasing time spent in a deep sleep by 20%. Phosphatidylserine Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. Elevated levels of cortisol throughout the night can contribute to frequent waking. When taken in the evening, PS can help reduce cortisol excretion from the body’s stress response system, the hypothalamic-pituitary-adrenal (HPA) axis, in order to promote a healthy sleep cycle. Taurine Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission by activating GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain. Mineral Blend Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Calcium ions are a critical requirement in the synthesis of melatonin. The combination of 5-HTP and calcium in Cerenity PM provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.
$41.62 - $72.87
Ortho Molecular Products® AdreneVive®
AdreneVive® is formulated to help respond to HPA axis loading, build stress resilience and maintain healthy HPA axis function. Improves Stress Resilience Supports Healthy Energy Levels Strengthens the Body’s Stress Response Improves Mental and Physical Performance Supports Healthy Cortisol Levels Stress is defined as any disturbance—extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure—that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Prolonged stress triggers the HPA axis and consists of three stages: alarm, resistance and exhaustion. The initial, short-lived phase is the body’s normal fight-or-flight response to danger which is characterized by elevated cortisol levels. The next phase, the resistance phase, allows the body to continue buffering extended stress exposure, long after the initial fight-or-flight response has dissipated. Hormones released by the adrenals, such as cortisol and DHEA, help support the "resistance" reaction. Extended periods of stress not only burden the system, creating an imbalance in cortisol and DHEA production, but can result in mental and physical fatigue, nervous tension, irritability and poor memory—all of which are characteristic of stage 3. AdreneVive® provides a unique blend of botanicals and nutrients that support the stress response, particularly promoting cortisol balance during the initial alarm phase. AdreneVive® includes a blend of adaptogenic botanicals and nutrients specifically formulated to counteract the effects of daily stress and support healthy energy levels. AdreneVive® provides a unique blend of "stress-adapting botanicals" that support the body’s resistance to fatigue and help to maintain balanced cortisol and DHEA levels. Suggested Use: 2 capsules taken one to two times per day or as recommended by your health care professional. L-Theanine L-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. The stress-buffering mechanisms of L-theanine have been connected to the ability of L-theanine to increase serotonin and dopamine production in the brain. L-theanine has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation. In a study using 16 healthy volunteers, electroencephalograph (EEG) readings of participants were recorded following the ingestion of 50 mg of L-theanine. The researchers found a greater increase in alpha brain wave activity versus placebo. L-theanine has also been shown to have a protective effect for nerve cells and reduces excitatory glutamate activity in the brain. Phosphatidylserine Phosphatidylserine is a phospholipid that is found in high concentrations in the brain. In studies administering phosphatidylserine (50-800 mg) to subjects under stress (physical, emotional, mental, etc.), it has been found that phosphatidylserine reduces stress-induced excretion of cortisol. Administration of phosphatidylserine has also been studied in exercising subjects. It has been demonstrated that phosphatidylserine reduces the cortisol response to overtraining resulting in a reduction in perceived muscle soreness and improvement in athletic performance. Ashwagandha Root Extract Ashwagandha’s strong adaptogenic properties provide an array of benefits for individuals that have compromised health due to extreme stress exposure. Ashwagandha’s benefits include improving stress resilience, supporting immune response, regulating the sleep cycle, supporting healthy thyroid function and protecting against exhaustion of the nervous system. Ashwagandha has also been shown to be beneficial in supporting proper mood regulation and restoring a sense of calmness under stress. Rhodiola rosea Root Extract Rhodiola rosea has been categorized as an adaptogenic botanical due to its ability to increase resistance to a variety of stressors. Rhodiola has been studied extensively and is widely used in Eastern Europe and Asia to help support the nervous system, mood regulation, mental clarity, work performance and the sleep cycle. Within the central nervous system, Rhodiola has demonstrated an ability to preserve levels of neurotransmitters, such as serotonin, dopamine and norepinephrine. In a randomized, double-blind, placebo-controlled study examining the effects of Rhodiola on fatigue and stress, 161 patients aged 19 to 21 years received Rhodiola twice daily resulting in a significant reduction in fatigue. An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability, and improved sleep patterns. Eleuthero Root Extract Eleutherococcus senticosus has also been identified as a strong adaptogenic botanical and is widely used in China to improve general health, support memory and endurance. In addition to its ability to improve stress resilience and fight fatigue, Eleuthero has exhibited immune supporting effects. In a double-blind study, 45 healthy volunteers received Eleuthero or placebo for 30 days. A cognitive challenge test was given to assess stress response, along with heart rate. Unlike placebo, subjects receiving Eleuthero demonstrated a 40% reduction in heart rate in response to the stressor. Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes). Skullcap Root Extract Native to China and parts of Russia, skullcap root (Scutellaria baicalensis) has been used in traditional Chinese medicine for its immune supporting properties. S. baicalensis has flavonoids which provide numerous protective effects including antioxidant activity and protection against unwanted organisms. Skullcap root has also been shown to support the proper activities of key mediators involved in the inflammatory response and protect against free radicals that cause lipid oxidation. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$57.77
Ortho Molecular Products® Reacted Magnesium
Reacted Magnesium includes three forms of highly absorbed magnesium for a variety of protocols. Provides Three Forms of Highly Absorbed Magnesium for a Variety of Protocols High-Concentration Magnesium for Cardiovascular Support Helps Maintain Healthy Blood Pressure and Glucose Levels Promotes Energy Production and Muscle Relaxation Magnesium is an abundant mineral in the body and is found naturally in many foods, like green leafy vegetables. It is also found in over-the-counter medications, such as laxatives. The average American intake of magnesium, according to the National Health and Nutrition Examination Survey (NHANES Study) is critically low: Many Americans fail to consume the estimated average requirement (EAR) established by the Institute of Medicine. In addition, more than 57% of the population does not meet the United States Department of Agriculture requirements for magnesium in the diet. Intracellular magnesium levels are decreased by excessive intake of alcohol, salt, coffee, phosphoric acid found in sodas, diets high in calcium and high stress levels. Because of widespread nature of magnesium deficiencies, adequate daily intake of magnesium is critical for proper hydration, stress response, muscle relaxation, promoting healthy blood pressure levels, optimal bone mineral density, and blood sugar regulation. Reacted Magnesium provides three unique forms of highly-absorbed magnesium to ensure maximum absorption of this important macromineral. Most magnesium supplements use only a single source of magnesium, which can easily overwhelm a single pathway of absorption and limit uptake. Reacted Magnesium takes advantage of three unique pathways of absorption by providing magnesium as di-magnesium malate, magnesium citrate and magnesium glycinate for enhanced absorption, improved utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of magnesium supplements, often experience GI side effects, including gas, bloating, diarrhea, constipation or a combination of these symptoms. The forms of magnesium used in Reacted Magnesium preserve GI comfort while maximizing absorption and restoring magnesium levels in the body. Suggested Use: 2 or more capsules per day or as recommended by your health care professional. Bioavailability - The Mineral Chelate Difference The importance of bioavailability is obvious. If consuming a magnesium supplement has little effect on improving the body’s magnesium balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms slow and limit absorption, relying on adequate stomach acid to release magnesium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). Reacted Magnesium provides the additional benefit of highly-absorbed, Albion® mineral chelates. Albion® is the world leader in manufacturing highly bioavailable mineral chelates, a specialized form of minerals bound to amino acids. This patented process creates organic mineral compounds which use active absorption mechanisms in the gastrointestinal tract to greatly enhance mineral absorption. In a magnesium comparison study reported by Graff et al. at Weber State University, Albion®’s magnesium amino acid chelate had: 8.8 times greater absorption than magnesium oxide 5.6 times greater absorption than magnesium sulfate 2.3 times greater absorption than magnesium carbonate In addition, other comparison studies have shown significantly superior absorption of magnesium chelates compared to other mineral forms: At a dose of 400 mg, magnesium chelate significantly reduced or eliminated menstrual abdominal discomfort. Multiple double blind studies found urinary excretion of magnesium chloride higher than magnesium glycinate, proving superior absorption. Magnesium glycinate is shown to have a reduced laxative effect when compared to other forms of magnesium. Mineral chelates are gentle, gut “friendly” minerals that do not cause diarrhea that often accompanies magnesium oxide and other rock-salt forms. Albion®’s mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability, and improved tolerance. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$20.01 - $58.42
Ortho Molecular Products® Vitamin K2 180 mcg
Highlights Vitamin K2 180 mcg is a high-concentration formula designed to support bone, cardiovascular and immune health. The formula includes MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7. Ortho Molecular Products is the exclusive supplier of MenaQ7® PRO. Supports Healthy Blood Circulation Promotes Optimal Bone Health and Proper Calcium Storage Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells which break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Current research has found high-concentration supplementation results in improved clinical outcomes compared to lower-dose supplementation. Vitamin K2 180 mcg provides an optimal dose of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7 to help support bone and cardiovascular health. Suggested Use: 1 capsule per day or as recommended by your health care professional. Vitamin K Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in three main forms: K1 (phylloquinone), found primarily in the liver, naturally occurs in green leafy vegetables and is considered to be the main dietary source; K2 (menaquinone), which is a group name for a family of related compounds differentiated by their side chains; and K3 (menadione), which does not have vitamin K activity. MK-4 and MK-7 are the two subclasses of K2 most widely studied for their role in bone and cardiovascular health. MK-4 is primarily a metabolic byproduct of K1 while MK-7 is found in small quantities in liver mitochondria and other tissues. The MK-7 form is substantially more active, has a longer half-life and accumulates to higher concentrations in serum than vitamin K1. The different degrees of bioavailability between K1 and K2 are due to differences in structure. The long side-chain of vitamin K2 (specifically MK-7) allows it to bind with fat particles in circulation. This process then allows easier facilitation to soft tissue, bones and arteries. More recently, research has shown that doses of 180 mcg of MK-7 provide greater results when supporting both bone and cardiovascular health. Vitamin K Depletion Although most people consume adequate dietary levels/amounts of vitamin K to maintain sufficient blood clotting, most do not consume enough MK-7 to meet cardiovascular and bone health needs. Compromised intestinal absorption can also lead to insufficient K2 levels, leaving calcium available to be exported out of bone and into other tissues. Other medications such as antibiotics, cholesterol-lowering medications and laxatives have also been found to contribute to a vitamin K deficiency. Bone Health Supplementation of K2 has repeatedly been shown to help maintain bone density and strength among women. Research from Japanese populations has found superior bone health among women who more frequently consumed MK-7 rich nattō than those who did not.12 The positive effect of K2 on bone health is also evident among healthy children, among whom modest supplementation with MK-7 has been shown to increase osteocalcin carboxylation. In a randomized, placebo controlled trial, 180 mcg of MK-7 or placebo were given to 244 healthy post-menopausal women over the course of three years. After at least two years, statistically significant benefits were seen in vertebrae, hip and femoral neck. Another ground-breaking randomized, placebo-controlled trial gave 244 women, aged 55-65, 180 mcg of vitamin K2 or placebo. The study found that those given the K2 were significantly better able to maintain their osteoclast to osteoblast ratio. Furthermore, levels of circulating osteocalcin, a marker related to tissue calcification in the body, were reduced by 50% among women taking K2 versus a 4% increase among the placebo group after two and three years. Cardiovascular Health and Blood Sugar Balance Vitamin K also plays a key role in supporting the cardiovascular system and healthy blood sugar balance. In a large population study, those who consumed high amounts of K2 had significantly improved cardiovascular markers compared to those given vitamin K1. A cohort of over 16,000 women also linked higher intake of K2 with better maintenance of cardiovascular health. Studies have also shown vitamin K to support healthy blood sugar metabolism. Doses of 180 mcg of K2 have been shown to have a positive effect on arterial and vascular elasticity. Additionally, 180 mcg of K2 given over two to three years has been shown to help maintain soft tissue health and vascular elasticity in healthy adult subjects.17 The same amount of MK-7 was also found to impart substantial benefits in arterial plasticity and blood vessel elasticity in healthy women, which had previously been only with “pharmacological doses” of synthetic vitamin K of up to 4,500 mcg daily. Triage Theory The Triage Theory states that in the face of nutrient inadequacies, nature ensures short term survival of a cell is protected at the expense of long term consequences. Vitamin K is an excellent example of this theory. Hypothetically, a short-term deficiency in vitamin K would lead to a reduction in blood clotting. This direct threat to survival does not happen, as the body uses its metabolic reserve of vitamin K to ensure immediate needs are met. If continued, this dip into reserve leads to a long term deficiency in vitamin K. Though not directly threatening immediate survival, long-term deficiencies are linked to bone fragility, arterial calcification and genomic instability. These issues are related to a loss of vitamin K-dependent proteins not required for short-term survival, nevertheless presenting long–term health challenges.
$43.66
Ortho Molecular Products® Vitamin D3 50,000 IU
In addition to supporting bone health, vitamin D plays an important role maintaining cardiovascular health and immune function, and promoting an overall sense of well-being. Product Overview Clinical Applications Maintains Bone and Dental Health Increases Calcium Absorption and Balance Boosts Immune Activity Supports Cardiometabolic Health, Blood Sugar Balance Already Within Normal Levels, and Weight Loss Helps Increase Musculoskeletal Strength and Comfort Vitamin D is a steroid hormone that is part of a group of fat-soluble pro-hormones best known for the role they play in supporting bone health and aiding in the absorption of calcium and phosphate from the gastrointestinal tract. A growing body of research highlights vitamin D's important role in supporting other body systems, including cardiovascular and blood sugar balance, musculoskeletal strength, and neurological and immune function, enabled by vitamin D's ability to target over 200 different genes throughout the body.Vitamin D3 50,000 IU is ideal for those who have difficulty achieving and maintaining peak vitamin D levels. For those who require an immediate boost in their vitamin D status, the vitamin D3 50,000 IU formulation is a convenient, effective way to get the substantial support they need. Suggested Use:1 capsule per week. This product is a high dose vitamin D capsule that is not typically intended for long-term daily use. Please consult your health care professional if you are unsure of the appropriate dose. Benefits Vitamin D DepletionWhile it has long been assumed that the majority of the population achieves adequate levels of vitamin D through exposure to the sun, the biosynthesis of the nutrient is affected by time of day, seasons, location, smog/pollution, clothing and sunscreen. Depleted levels of vitamin D may interfere with the normal development of teeth and bones, normal cell growth, and contribute to poor regulation of immune and nervous systems. Bone and Dental HealthNumerous studies have highlighted the importance of vitamin D to maintaining healthy bone density.Cardiometabolic Health and Blood Sugar BalanceIn light of the role that vitamin D plays in a variety of tissues and body systems, it comes as no surprise that much research from recent years has underscored its contribution to cardiometabolic wellness. Vitamin D has also been shown to support healthy blood sugar metabolism. Immune Health and ModulationOne of the more profound functions of vitamin D is its ability to modulate immunity. An important recent study suggested that improving vitamin D status significantly affects the expression of genetic pathways linked to immune activity. Vitamin D has been shown to boost the immune response by up-regulating specific genes.Musculoskeletal ComfortNumerous studies also point to the key role of vitamin D in supporting musculoskeletal strength and comfort.Safety and Efficacy of High Dose Vitamin DVitamin D research is continually evolving and now includes safety and efficacy studies on high doses of up to 50,000 IU. Vitamin D 50000 Supplement Facts Serving Size 1 Capsule Servings Per Container 15 Amount Per Serving % Daily Value Vitamin D (D3 as Cholecalciferol) 1,250 mcg (50,000 IU) 6,250%
$9.62 - $88.80
Ortho Molecular Products® Ortho Spore IG™
Ortho Spore IG™ is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to and eliminate microbes and toxins that are common in SIBO. Helps Maintain Normal Gastrointestinal Balance Provides Concentrated Immunoglobulins to Enhance Mucosal Immunity Supports Digestion and Micronutrient Absorption Maintains GI Barrier Health and Integrity SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling. Probiotics have been extensively studied and are characterized as having broad GI and immune benefits. Probiotics are live organisms and must be shelf stable through the expiration date, so they can be precisely delivered to the intestinal tract to have maximum benefit. Bacillus spores remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. The combination of specific strains, particularly Bacillus coagulans, Bacillus clausii, and Bacillus subtilis, relieve symptoms for common GI complaints and reinforce healthy gut function. In the search for innovative ways to improve microbiome diversity, we have combined our blend of spore-forming probiotics alongside immunoglobulins uniquely shown to bind to bacteria and toxins, driving immune response. IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen. Suggested Use: 3 capsules per day or as recommended by your health care professional. Bacillus coagulans Bacillus coagulans has been shown to increase the commensal GI microbiota. It has been shown to relieve GI discomfort and improve stool consistency. B. coagulans also significantly improved bowel movements in healthy adults with occasional constipation, as well as decreased abdominal discomfort. Bacillus clausii B. clausii is commonly used as a probiotic to promote balance in the microbiome and has showed promising results in individuals with SIBO. B. clausii has demonstrated significant effectiveness in adults with acute diarrhea. B. clausii has also shown to significantly reduce duration of occasional diarrhea and decreased stool frequency in children Bacillus subtilis Bacillus subtilis has been shown to relieve GI distress in patients. Serum-derived bovine immunoglobulins Probiotics are a natural choice for supporting beneficial bacteria in the gut, but supplementation to eliminate unwanted microbes should also be considered. Within the gut barrier, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function in vitro. Broad-spectrum binding capabilities demonstrate the positive influence of serum-derived bovine immunoglobulins. This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$61.10
Ortho Molecular Products® Methyl CpG®
Highlights Methyl CpG® is a comprehensive formula that includes targeted amounts of five key nutrients designed to support methylation and homocysteine balance in the body. Supports Optimal Methylation and Cardiovascular Health Supports Healthy Homocysteine Levels Increases Neurotransmitter Production Supports Primary Detoxification Pathways Promotes DNA Repair Methylation is a vitamin-requiring biochemical process in the body that is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins. Methyl CpG® provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. The formula includes key methylation vitamins B2, B6 and B12 (methylcobalamin). This specific blend of methyl donors promotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification. Suggested Use: 1 capsule per day or as recommended by your health care professional. Folate Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is abundantly found in foods such as fruits and dark leafy vegetables but, can be easily destroyed by cooking or processing. The bioactive form of folate is 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is required as a methyl group donor for several processes, including the production of mood regulating neurotransmitters, the synthesis of melatonin, and DNA production and repair. Vitamin B12 Vitamin B12 works with folate in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly run the highest risk of B12 deficiency. Methylcobalamin is the preferred form of B12 as it is the biologically active form of B12 and supports the up-regulation of methylation pathways. Vitamin B6 Vitamin B6 is a crucial B vitamin that is involved in the production of proteins in the body, neurotransmitters that help regulate mood, red blood cell formation and the proper functioning of the immune system. B6 is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with 5-MTHF and B12 in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining normal blood pressure. Vitamin B2 Optimizing B2 (riboflavin) status helps support healthy blood pressure. Supporting riboflavin status also appears to stabilize MTHFR, the enzyme required for 5-MTHF which converts homocysteine to methionine. Trimethylglycine (Betaine) As a methyl donor, trimethylglycine supports liver function, including detoxification pathways. Trimethylglycine has been shown to protect against chemical damage to the liver. It has also been shown to be beneficial in protecting against fat accumulation in the liver, due to its lipotropic properties. Trimethylglycine also works alongside B2, B6, B12 and folate in maintaining normal homocysteine levels.
$46.01
Ortho Molecular Products® Nattokinase
Highlights Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels. Supports Healthy Blood Flow and Circulation Supports Healthy Fibrin Levels Helps Maintain Healthy Blood Pressure Supports Overall Cardiovascular Health Maintaining healthy blood circulation and balanced coagulation is a key part of supporting cardiovascular health. Fibrinolytic enzymes, such as plasmin, produced in the endothelial cells are responsible for ensuring proper blood flow. However, production of these enzymes decreases with age, which can result in increased fibrin levels. Nattokinase also inhibits a key enzyme resulting in arterial dilation to help maintain healthy blood pressure levels, and can generate tissue plasminogen activators helping to promote blood flow. Because it is a highly purified extract derived from soybeans, supplementing nattokinase differs from consuming soybeans in that nattokinase escapes the typical breakdown by digestive enzymes, and is absorbed and taken into the body directly from the small intestine to exert its effects in the plasma. Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and blood pressure levels. Derived from a highly purified extract of the traditional Japanese food natto, nattokinase is a natural, highly active enzyme that helps promote normal levels of fibrin. Fibrin is a filamentous protein formed in blood, which can accumulate along blood vessel walls and affect blood flow. Research has shown nattokinase closely resembles plasmin, the only endogenous enzyme that directly dissolves fibrin. It is thought to increase the body’s production of plasmin. Nattokinase has been shown to support activation of many of the body’s 3,000 endogenous enzymes. In addition, while many of the agents involved in promoting healthy blood flow and coagulation either have limitations, and or serious side effects, this formulation of Nattokinase has a potent support activity that lasts for an 8-12 hour period and is safe for long-term use. Each capsule of Nattokinase contains 100 mg of nattokinase. Suggested Use: 1 soft gel capsule two times per day or as recommended by your health care professional.
$39.27
Ortho Molecular Products® Sinatrol®
Highlights The standardized botanical extracts and nutrients in Sinatrol® support sinus health by reducing the viscosity of mucus, clearing airway passages, and promoting nasal microbial and inflammatory balance. Also available in convenient blister packs. Provides Support for Sinus and Respiratory Challenges Boosts Immune Response Helps Soothe Sinus Tissue Optimal sinus health requires adequate mucus flow and clearance throughout the nasal cavities. The sinuses are hollow cavities branching from the nasal passages. While the nasal passages are often colonized with bacteria, the sinuses are typically sterile under healthy conditions. The sinuses and nasal passages are lined with soft tissue, called mucosa, that feature thin, hair-like projections called cilia. Specialized cells of the mucosal tissue, known as goblet cells, secrete a thin layer of mucus to absorb microbes and allergens, such as dust, dirt, pollen, and mold, inhaled through the nose. Working together, cilia "beat" to move mucus and waste out of the sinuses and nasal passages. Upper respiratory challenges may impair this process, known as mucociliary clearance, and contribute to fluid entrapment within the sinus cavities. Sinatrol® contains a synergistic blend of nutrients and botanical ingredients to quickly boost immune response, decrease mucus build-up and increase mucociliary clearance during upper respiratory challenges. Sinatrol® is a unique nutrient and botanical formulation providing effective support for upper respiratory challenges. Standardized botanical extracts and nutrients support sinus health by reducing the viscosity of mucus, clearing airway passages, and promoting nasal microbial and inflammatory balance. Suggested Use: 3 capsules per day or as recommended by your health care professional. N-Acetyl Cysteine N-acetyl cysteine (NAC) is a powerful amino acid that decreases the thickness of mucus. NAC helps to dissolve mucus by breaking disulfide bonds that create mucus density, allowing for easier drainage of mucus. NAC is also a precursor to the body’s most powerful antioxidant, glutathione, which is an essential component of a healthy immune response. Turmeric Root (Complete Turmeric Matrix) Whole-root turmeric and its active components have been used in traditional Ayurvedic medicine for centuries. New research on turmeric shows the additional bioactives in turmeric have additional benefits and enhance bioavailability. The Complete Turmeric Matrix includes compounds from the entire turmeric root, all working together as nature intended to deliver better results. The Complete Turmeric Matrix has shown to deliver the benefits of the whole turmeric root that enables it to have a potent effect on the immune system and maintain normal inflammatory balance. Bromelain Bromelain is a plant enzyme naturally found in the stem and fruit of the pineapple plant. Bromelain exerts a synergistic effect when combined with NAC due to its proteolytic (protein digesting) actions. Bromelain has been found effective for thinning nasal secretions with the additional benefit of balancing inflammatory responses. Berberine Sulfate Berberine sulfate is a botanical extract found in the root and bark of various plants including Oregon grape root and barberry. Berberine extract has been shown to support immune responses by increasing blood flow to the spleen and activating immune cells, such as macrophages. Berberine maintains healthy sinus function by quieting localized inflammatory response through inhibition of activator protein 1 (AP-1) and thromboxane A2 from platelets. Chinese Licorice Root Extract Chinese licorice (Glycyrrhiza uralensis) and common licorice root (Glycyrrhiza glabra) have been used in Eastern and Western cultures for thousands of years. The active components in licorice, glycyrrhizin and glycyrrhetinic acid, strengthen the immune response by inducing interferon activity, activating macrophages and augmenting natural killer cell activity. Glycyrrhizin exerts an inflammatory balancing response by inhibiting production of free radicals by neutrophils. Andrographis Leaf Extract Andrographis paniculata has been used in Eastern medicine for centuries. The immune boosting properties of andrographis have been researched extensively in clinical studies. In seven double-blind controlled trials, andrographis was found to be a safe and effective botanical for supporting upper respiratory tract health. Eleuthero Root Extract Eleuthero root extract has been shown to support the immune response, especially in combination with andrographis. Two randomized, double-blind, placebo-controlled trials of the combination of Eleuthero and andrographis demonstrated the efficacy of this combination for respiratory challenges. Thyme Herb Extract Thyme has been traditionally used to soothe sinuses and loosen phlegm. Thymol, the active ingredient in thyme, has immune supporting properties and competes with immune system triggers commonly found in the sinuses and respiratory tract.
$39.58
Ortho Molecular Products® Adren-All®
The special blend of vitamins and adaptogenic herbs in Adren-All® support normal adrenal function during occasional stress and fatigue. Improves Stress Resilience Supports Healthy Energy Levels Strengthens the Body’s Stress Response Improves Mental and Physical Performance Helps Maintain a Balanced Cortisol-to-DHEA ratio Stress is defined as any disturbance–extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure, that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Prolonged stress triggers the HPA axis and consists of three stages: stage 1: alarm; stage 2: resistance; and stage 3: exhaustion. The initial, short-lived phase (the alarm phase) is the body’s normal fight-or-flight response to danger which is characterized by elevated cortisol levels. The next phase, the resistance phase, allows the body to continue buffering extended stress exposure, long after the initial fight-or-flight response has dissipated. Hormones released by the adrenals, such as cortisol and DHEA, help support the "resistance" reaction. However, extended periods of stress not only burden the system, creating an imbalance in cortisol and DHEA production, but can result in mental and physical fatigue, nervous tension, irritability and poor memory-all of which are characteristic of stage 3. Adren-All® offers a unique blend of botanicals, adrenal concentrate and micronutrients that support the adrenals glands, as well as the body’s ability to respond to and counter-act the negative effects of stress. Adren-All® contains a blend of key micronutrients, adaptogenic botanicals and adrenal concentrate specifically formulated to strengthen the body’s stress response and support healthy energy levels. Adren-All® provides targeted amounts of vitamin A and C, pantothenic acid, and other B vitamins that are critical to adrenal gland function. This powerful formulation helps support the body’s resistance to fatigue and aids in maintaining balanced cortisol and DHEA levels. Suggested Use: 2 capsules one to two times per day or as recommended by your health care professional. Rhodiola rosea Root ExtractRhodiola rosea has been categorized as an adaptogenic botanical due to its ability to increase resistance to a variety of stressors. Rhodiola has been studied extensively andis widely used in Eastern Europe and Asia to help support the nervous system, mood regulation, mental clarity, work performance and the sleep cycle. Within the central nervous system, Rhodiola has demonstrated an ability to preserve levels of neurotransmitters such as serotonin, dopamine and norepinephrine. In a randomized, double-blind, placebo-controlled study examining the effects of Rhodiola on fatigue and stress, 161 patients aged 19 to 21 years received Rhodiola twice daily resulting in a significant reduction in fatigue. An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability, and improved sleep patterns.Eleuthero Root ExtractEleutherococcus senticosus has been identified as a strong adaptogenic botanical and is widely used in China to support general health, memory and endurance. In addition to its ability to improve stress resilience and fight fatigue, Eleuthero has exhibited immune supporting effects. In a double–blind study, 45 healthy volunteers received Eleuthero or placebo for 30 days. A cognitive challenge test was given to assess stress response, along with heart rate. Unlike placebo, subjects receiving Eleuthero demonstrated a 40% reduction in heart rate in response to the stressor. Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes).Schizandra Berry ExtractSchizandra is an adaptogenic botanical that has been used for centuries in China and Russia to help support mental clarity, stress response and emotional wellness. In a double-blind, placebo-controlled study, athletes who were given an adaptogenic blend including Schizandra chinensis extract or placebo, had increased concentrations of nitric oxide, a molecule which causes the blood vessels to expand resulting in increased circulation, increased blood flow and nutrients throughout the body and healthy blood pressure. The researchers concluded that Schizandra enhances physical performance in athletes. Schizandra berry has been shown to support learning and memory and may have a protective effect on brain health.Licorice Root ExtractThe primary components in licorice root that support adrenal health include glycyrrhetic acid and glycyrrhizin. Licorice has also been shown to block 11-ß-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive cortisone. When taken in small doses, licorice root extract can be used to maintain cortisol levels, an important factor for individuals that need to support adrenal hormone production and maintain healthy inflammatory pathways.Adrenal ConcentrateThe use of glandular concentrates to supply key nutrients to support the body has been used in medicine for thousands of years. The concept behind glandular therapy is based on the idea that similar organ extracts from animals will support the same organ within humans by stimulating its activity.Adrenal bovine concentrate allows for rejuvenation of the adrenal stress system in a balanced and efficient manner.Micronutrient BlendAdrenal gland function, as well as the synthesis of cortisol, is dependent on an adequate supply of various vitamins. Vitamin C levels are among the highest in the adrenal glands compared with other organs. Vitamin C plays a major role in neurotransmitter production and supports general health of the adrenals. Under stressful conditions, vitamin C and B complex vitamins are readily used and excreted from the body. Within the B vitamin family, pantothenic acid breaks down into coenzyme A, which is essential for the production of energy from ingested carbohydrates, fats and proteins. In a study evaluating the effects of pantothenic acid and glutathione production, pantothenic acid was found to increase CoA levels in the body, leading to increased energy production. Niacin also plays a vital role in many metabolic functions in the body, including supplying energy to cells and assisting in the production of adrenal hormones. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$34.23
Ortho Molecular Products® Strontium
Strontium is a mineral that is similar physical and chemical properties to calcium. Research has shown strontium provides all-natural bone support. Provides Musculoskeletal Support Provides All-Natural Bone Support Increases Skeletal Strength and Helps Maintain Bone Density Bone is the rigid structure that makes up our skeleton, but is actually an active, living organ that is constantly being built up and broken down by osteoblasts and osteoclasts. The proper balance of this cycle and turnover of bone provides the foundation for strong bones over a lifetime.Strontium is a mineral that is similar physical and chemical properties to calcium. Research has shown strontium provides all-natural bone support through its ability to naturally increase the formation of osteoblasts (cells that build up bone) and slow down the formation of osteoclasts (cells that break down bone tissue), helping to maintain healthy bone density.Suggested Use:1 capsule two times per day or as recommended by your health care professional. For maximum absorption, do not consume with calcium supplements. Bone and Skeletal HealthA growing body of research highlights the benefits of strontium in skeletal health. A head-to-head study comparing SrC to strontium ranelate (SrR) in rats found both forms deliver equivalent amounts of elemental strontium. In the study, equivalent doses of both forms of strontium or placebo were given and assimilation into bone was compared for 19 weeks and followed for another eight weeks. The study confirmed the equivalent delivery of SrC into bone compared to SrR and potential of SrC to support bone structure. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
$24.60
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